Table 1.

Studies with CBD addressing motor symptoms in PD

Symptom	Design	Sample size	Duration	Primary outcome	Application form	Dosage	Outcome	References
Motor symptoms	Double-blind, randomized, placebo-controlled crossover study	17	2 × 4 weeks, 2 weeks wash-out phase	UPDRS	Orally	2.5 mg THC + 1.25 mg CBD (Cannador) or placebo	No positive effect compared with placebo	Carroll et al. [89]
	Open-label pilot	6	4 weeks	UPDRS total	Orally	150–400 mg/day CBD or Placebo	CBD did not worsen the motor function and decreased the total scores of UPDRS	Zuardi et al. [165]
	Randomized, double-blind, placebo-controlled study	21	6 weeks	UPDRS total	Orally	1. Group: CBD 75 mg/day	UPDRS unchanged	Chagas et al. [60]
						2. Group: CBD 300 mg/day
						3. Placebo group
	Phase II/III, randomized double-blind, placebo-controlled clinical trial	33	14 weeks	UPDRS	Orally	75 or 300 mg/day CBD or placebo	No significant difference between groups	de Almeida et al. [86]