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. 2024 Oct 23;2024:9962512. doi: 10.1155/2024/9962512

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Copyright © 2024 Kévin Boumeghar et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Blast morphology and evolution of blasts over time. Blasts morphology of TAM-DS and ML-DS are characterized by the presence of large cells with round nuclei and “blebs,” irregular protrusions of the cell membrane, altogether suggesting a megakaryoblastic origin. The morphology of blasts in TAM-DS (cases 1 and 2) exhibited no significant differences compared to blasts in ML-DS (cases 3 and 4). In case 3, rare granulations were visible. In case 4, bone marrow analysis revealed dysmegakarocytopoiesis including the presence of micromegakaryocytes (May Grünwald Giemsa, original magnification 1000x). In TAM-DS cases, evolution of blast count in blood is illustrated, showing a decrease after a few days. For ML-DS cases, blast counts in the bone marrow are presented along with platelet counts and their evolution after treatment. ML-DS, myeloid leukemia associated with down syndrome; TAM, transient abnormal myelopoiesis.