Table 5. Surgical approach and outcome of patients with sinonasal malignancy patients with brain invasion and neurological deficits who underwent upfront surgical resection without induction chemotherapy.
| Surgical cohort with brain invasion | Surgical cohort with neurological deficit | |
|---|---|---|
| Total patients | 16 | 8 |
| Surgical approach | ||
| Anterior transcranial | 9 (56.3%) | 3 (37.5%) |
| Ant transcranial, transfacial | 1 (6.25% | 4 (50.0%) |
| Ant transcranial, endoscopic | 5 (31.3%) | 1 (12.5%) |
| Endoscopic | 1 (6.25%) | – |
| Extent of resection | ||
| GTR | 11 (68.7%) | 6 (75.0%) |
| Negative margins | 7 (43.7%) | 6 (75.0%) |
| Post-op adjuvant treatment | ||
| Chemotherapy | 5 (31.3%) | 1 (12.5%) |
| Radiation | 11 (68.7%) | 3 (37.5%) |
| Chemotherapy + radiation | 4 (25.0%) | 0 |
| Long-term disease control outcomes | ||
| Recurrence rate | 9 (56.3%) | 5 (62.5%) |
| PFS (mo) | 39.1, SD 35.7 mo | 34.2, SD: 71.6 mo |
| OS (mo) | 84.9, SD 69.5 mo | 87.1, SD: 115 mo |
Abbreviations: GTR, gross total resection; OS, overall survival; PFS, progression-free survival; SD, standard deviation.