TABLE 1.
Genotyped variants and alleles in which those variants are present.
| Gene | Allele | Variants present in the allele | European allele frequency | Latin-american allele frequency |
|---|---|---|---|---|
| ABCB1 | N/A | rs1128503 | 0.57 | 0.52 |
| N/A | rs1045642 | 0.48 | 0.55 | |
| N/A | rs2032582 a | 0.55 (C), <0.01(T) | 0.54 (C), <0.01(T) | |
| ABCC2 | N/A | rs2273697 | 0.20 | 0.16 |
| SLC22A1 | N/A | rs72552763 | 0.15 | 0.27 |
| N/A | rs12208357 | 0.07 | 0.02 | |
| N/A | rs34059508 | 0.02 | 0.01 | |
| SLCO1B1 | *5 | rs4149056 b | 0.02 | 0.00 |
| *15 | rs4149056, rs2306283 b | 0.15 | 0.24 | |
| *37 | rs2306283 b | 0.25 | 0.39 | |
| CYP1A2 | N/A | rs2470890 | 0.35 | 0.66 |
| N/A | rs2069514 | 0.01 | 0.34 | |
| N/A | rs762551 | 0.70 | 0.69 | |
| CYP2A6 | *9 | rs28399433 | 0.06 | 0.04 |
| CYP2B6 | *4 | rs2279343 | 0.04 | 0.11 |
| *5 | rs3211371 | 0.12 | 0.04 | |
| *6 | rs2279343, rs3745274 | 0.23 | 0.21 | |
| *7 | rs2279343, rs3211371, rs3745274 | 0.02 | 0.01 | |
| *9 | rs3745274 | 0.01 | 0.07 | |
| CYP2C19 | *2 | rs4244285 | 0.15 | 0.10 |
| *3 | rs4986893 | <0.01 | <0.01 | |
| *4 | rs28399504 | <0.01 | <0.01 | |
| *17 | rs12248560 | 0.22 | 0.17 | |
| CYP2C8 | *2 | rs11572103 | <0.01 | <0.01 |
| *3 | rs10509681 | 0.12 | 0.08 | |
| *4 | rs1058930 | 0.04 | 0.01 | |
| CYP2C9 | *2 | rs1799853 | 0.13 | 0.08 |
| *3 | rs1057910 | 0.08 | 0.04 | |
| CYP2D6 | *3 | rs35742686 | 0.02 | 0.01 |
| *4 | rs3892097, rs1065852 | 0.19 | 0.12 | |
| *6 | rs5030655 | 0.01 | 0.01 | |
| *7 | rs5030867 | <0.01 | 0.00 | |
| *8 | rs5030865 | <0.01 | 0.00 | |
| *9 | rs5030656 | 0.03 | 0.02 | |
| *10 | rs1065852 | 0.02 | 0.03 | |
| *14 | rs5030865 | 0.00 | 0.00 | |
| *17 | rs28371706 | <0.01 | 0.02 | |
| *41 | rs28371725 | 0.09 | 0.05 | |
| CYP3A4 | *2 | rs55785340 | <0.01 | 0.00 |
| *6 | rs4646438 | <0.01 | 0.00 | |
| *22 | rs35599367 | 0.05 | 0.03 | |
| CYP3A5 | *3 | rs776746 | 0.92 | 0.77 |
| *6 | rs10264272 | <0.01 | 0.04 | |
| UGT1A1 | *80 | rs887829 | 0.31 | 0.38 |
| UGT1A3 | N/A | rs2008584 | 0.44 | 0.47 |
| UGT1A4 | N/A | rs2011425 | 0.08 | 0.01 |
| UGT1A6 | N/A | rs10445704 | 0.40 | 0.27 |
| UGT1A8 | N/A | rs1042597 | 0.22 | 0.02 |
| UGT1A9 | N/A | rs10929302 | 0.29 | 0.30 |
| UGT2B7 | N/A | rs7668258 | 0.48 | 0.71 |
| UGT2B10 | N/A | rs61750900 | 0.07 | 0.00 |
| UGT2B15 | N/A | rs1902023 | 0.48 | 0.61 |
N/A: not applicable. Allelic frequency data was collected from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the National Institutes of Health (NIH) SNP, databases.
a
As this is a triallelic variant, the allele frequencies for the two alternatives are shown.
b
As allelic references for Latin Americans are not available in CPIC, those for Americans are reflected globally.