TABLE 4.
Ezetimibe pharmacokinetic parameters based on genotypes or phenotypes.
| N | AUC72h/DW (h a ng a kg/mL a mg) | Cmax/DW (ng a kg/mL a mg) | tmax (h) | |
|---|---|---|---|---|
| ABCB1 (rs1128503) | p = 0.164 | p = 0.245 | p = 0.146 | |
| T/T | 29 | 697.48 (281.49) | 36.01 (16.98) | 5.50 (0.75–6.00) |
| T/C | 43 | 783.10 (291.38) | 37.05 (19.68) | 6.00 (1.75–6.50) |
| C/C | 24 | 654.98 (261.32) | 30.26 (15.14) | 3.25 (1.50–6.38) |
| ABCB1 (rs1045642) | p = 0.366 | p = 0.555 | p = 0.958 | |
| T/T | 24 | 655.13 (232.91) | 31.82 (11.61) | 5.50 (0.75–6.38) |
| T/C | 42 | 761.85 (284.24) | 36.97 (18.73) | 5.50 (1.25–6.00) |
| C/C | 30 | 729.98 (316.49) | 34.89 (20.74) | 5.50 (1.50–6.50) |
| ABCB1 (rs2032582) | p = 0.299 | p = 0.056 | p = 0.493 | |
| T/T | 17 | 642.81 (280.73) | 28.02 (13.69) | 6.00 (1.75–6.50) |
| T/G + T/A | 28 | 745.50 (268.91) | 33.91 (16.28) | 4.25 (1.50–6.00) |
| G/G + A/A+ G/A | 50 | 746.37 (293.68) | 38.25 (19.54) | 5.50 (1.19–6.50) |
| ABCC2 (rs2273697) | p = 0.137 | p = 0.074 | p = 0.995 | |
| G/G | 68 | 714.18 (269.98) | 34.93 (17.18) | 5.50 (1.50–6.38) |
| G/A | 25 | 715.89 (309.92) | 32.73 (18.91) | 5.50 (1.00–6.25) |
| A/A | 3 | 1,052.81 (243.58) | 56.59 (15.32) | 6.00 (1.00–6.00) a |
| SLCO1B1 | p = 0.221 | p = 0.914 | p = 0.373 | |
| NF | 76 | 700.50 (271.62) | 35.13 (18.90) | 5.50 (1.25–6.00) |
| DF | 19 | 830.65 (319.11) | 34.54 (14.04) | 6.00 (1.75–6.00) |
| PF | 1 | 599.21 | 37.21 | 7.00 |
| UGT1A1 | p = 0.247 | p = 0.407 | p = 0.679 | |
| NM | 44 | 685.06 (302.40) | 34.25 (18.81) | 5.75 (1.56–6.00) |
| IM | 43 | 745.03 (258.16) | 33.81 (13.20) | 5.50 (1.00–6.00) |
| PM | 8 | 820.20 (321.81) | 44.26 (31.33) | 5.75 (2.13–6.38) |
| UGT1A3 (rs2008584) | p = 0.586 | p = 0.163 | p = 0.229 | |
| A/A | 22 | 676.81 (264.31) | 28.76 (11.78) | 6.00 (1.69–6.50) |
| A/G | 33 | 758.63 (310.61) | 37.58 (18.99) | 3.00 (1.00–6.00) |
| G/G | 19 | 713.59 (308.52) | 31.35 (11.25) | 5.50 (2.00–6.50) |
| UGT2B15 (rs1902023) | p = 0.400 | p = 0.815 | p = 0.742 | |
| A/A | 16 | 782.84 (311.45) | 33.18 (16.49) | 6.00 (1.81–6.00) |
| A/C | 47 | 681.01 (285.78) | 31.77 (15.52) | 5.50 (1.50–6.00) |
| C/C | 17 | 737.18 (251.17) | 33.22 (12.83) | 6.00 (0.75–8.25) |
Data are shown as mean (standard deviation) for normal distributions and median (Q25-Q75) for non-normal distributions. AUC: area under the curve. DW: dose/weight ratio. Cmax: maximum concentration. tmax: time to Cmax. p-value of the group is shown.
a
It is not possible to generate quartiles, therefore, the range of the data is shown for this result.