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Irisin is produced by exercise. In response to exercise peroxisome proliferator, PGC-1α, leads to the production of FNDC5, a protein which contains an N-terminal signal sequence (blue); fibronectin III (green); a transmembrane region (TR) (red); a cytosolic region with a C-terminal tail (yellow). The proteolytic cleavage of mature FNDC5 results in the release of irisin.
