TABLE 1.

Changes in FNDC5 and/or irisin levels after exercise.

Species	Motion type	Level change	References
C57BL/6J mice	Treadmill exercise	Irisin (plasma) ↑ FNDC5 mRNA and protein (muscle) ↑	Pang et al. (2018)
Wistar rats	Treadmill exercise	FNDC5 protein (hippocampal) ↑	Babaei et al. (2021)
Outbred mouse line DUhTP	Running-wheel exercise Treadmill exercise	Irisin (plasma and muscle) ↑ FNDC5 protein (muscle) —	Brenmoehl et al. (2014)
Mice	Running-wheel exercise	FNDC5 mRNA (hippocampal) ↑	Wrann et al. (2013)
C57BL/6 J mice	Treadmill exercise	Irisin (plasma) ↑ FNDC5 mRNA and protein (muscle) ↑	Park et al. (2022)
Homo sapiens	Acute exercise Chronic exercise	Serum irisin decreased after chronic exercise and increased after acute exercise	Norheim et al. (2014)
Homo sapiens	Aerobic exercise	Irisin (plasma) ↑	Kraemer et al. (2014)
Homo sapiens	Acute exercise Chronic exercise	Serum irisin was upregulated after acute exercise	Huh et al. (2012)
Homo sapiens	Endurance exercise Resistance exercise	Increased plasma irisin levels after resistance exercise	Tsuchiya et al. (2015)