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β-Elemene inhibits the interaction between OTUB1 and GPX4 in Radioresistant GC cells. (A) Potential interacting proteins of GPX4 predicted using the IntAct online database. (B–C) IF experiments and mIHC validate the colocalization of GPX4 and OTUB1 in MKN-45/IR and AGS/IR cells. Scale bar, 10 μm. (D–E) Co-immunoprecipitation (Co-IP) assays to detect the interaction between GPX4 and OTUB1 in MKN-45/IR and AGS/IR cells treated with radiation (4 Gy) with or without β-elemene (100 mg/L).
