TABLE 5.

Oral microbiota related to development of osteoarthritis.

No	Studies	Outcomes	References
1	Reviewing the salivary microbiome in 155 healthy controls, 110 rheumatoid arthritis (RA) patients, and 67 osteoarthritis (OA) patients. The ages of the subjects were 49.96 ± 11.17, 56.65 ± 11.36, and 57.79 ± 9.712, respectively	5 Eight OTUs—Actinomyces, Neisseria, Neisseria subflava, Haemophilus parainfluenzae, Haemophilus, Veillonella dispar, Prevotella, and Veillonella—are identified as potential biomarkers with the highest AUC of 0.87 6 Healthy patients have a higher relative abundance of Proteobacteria compared to patients with rheumatoid arthritis (RA) or osteoarthritis (OA) 7 Healthy patients have a lower relative abundance of Firmicutes compared to patients with RA or OA. 8 Alpha diversity is increased in OA patients compared to the healthy group	Chen et al. (2018)