Figure 2.

Proteomics of incident HF in two independent studies (the FHS and UK Biobank)

(A) Volcano plots in FHS (adjusted for age and gender) and UK Biobank (adjusted for age, gender, race). Blue color indicates <5% FDR. Note that in the FHS where SomaScan proteomics was used, there can be multiple aptamers for the same protein (e.g., F9).

(B) Pathway analysis of the 134 targets (KEGG, Reactome) prioritized by echocardiographic associations with LV systolic function, LV diastolic function, and LV morphology, which were associated with incident HF in FHS or UK Biobank. The assayed proteome from CARDIA was used as background. p.adjust indicates FDR-corrected p values.