Table 1.
Main characteristics of the included studies.
| N | Author, Year | Country | N. of case | Age | Sex | Filler | ADR type | Site | Onset (time after injection, months) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Fernandez Acenero M. J., 2003 (20) | Spain | 1 | 48 | F | Hyaluronic acid | Granulomatous foreign body reaction | Upper lip | 2 |
| 2 | Schmidt-Westhausen A.M., 2004 (21) | Germany | 1 | 56 | F | Silicone | Abscess | Lower lip | 12 |
| 3 | Dijkema J.S., 2005 (22) | Netherlands | 1a | 64 | F | Poly-L-lactic acid | Granulomatous foreign body reaction | Upper lip | 14 |
| 4 | Leonhardt J.M., 2005 (23) | USA | 1 | 52 | F | Hyaluronic acid | Angioedema | Upper lip | 0 |
| 5 | Edwards P.C., 2006 (24) | USA | 1 | 74 | F | Hyaluronic acid | Granulomatous foreign body reaction | Lower lip | 6 |
| 6 | Sanchis-Bielsa J.M., 2009 (25) | Spain | 9b | 63 | F | Silicone | Granulomatous foreign body reaction | Perioral and buccal mucosa | 168 |
| 70 | F | Collagen | 24 | ||||||
| 55 | F | Silicone | 108 | ||||||
| 37 | M | Polyalkylimide | 84 | ||||||
| 54 | F | Silicone | 120 | ||||||
| 41 | F | Collagen | 60 | ||||||
| 69 | F | Silicone | 120 | ||||||
| 53 | F | Hyaluronic acid | 48 | ||||||
| 40 | Silicone | n.d. | |||||||
| 7 | Dionyssopoulos A., 2007 (26) | Greece | 1 | 45 | F | Poly-L-lactic acid | Granulomatous foreign body reaction | Both lips | 18 |
| 8 | Weyand B., 2008 (27) | Germany | 1 | 62 | F | Mixed (Hyaloronic Acid + Hydroxyethyl Methacrylate + Ethyl Methacrylate) | Granulomatous foreign body reaction and pseudomonas superinfection | Both lips | n.d. |
| 9 | da Costa Miguel M.C., 2009 (28) | Brazil | 1 | 56 | F | Polymethylmethacrylate immersed in a solution of collagen | Granulomatous foreign body reaction | Right anterior inferior alveolar mucosa | 12 |
| 10 | Shahrabi Farahani S., 2012 (29) | USA | 3 | 55; 57; 56. |
F | Hyaluronic acid | Granulomatous foreign body reaction | Upper lip Lower lip Lower lip. |
4; 24; n.d. |
| 11 | Lee S.C., 2013 (30) | Korea | 1 | 50 | F | Polymethylmethacrylate immersed in a solution of collagen | Granulomatous foreign body reaction | Upper lip | n.d. |
| 12 | Bulam H., 2015 (31) | Turkey | 1 | 27 | F | Hyaluronic acid | Angioedema | Both lips | 0 (at the same time) |
| 13 | Curi M.M., 2015 (32) | Brazil | 1 | 65 | F | Hyaluronic acid | Granulomatous foreign body reaction | Upper lip | 144 |
| 14 | Alghonaim Y.A., 2016 (33) | Canada | 1 | 52 | F | Hyaluronic acid | Granulomatous foreign body reaction | Lower lip | 1 |
| 15 | Paolino G., 2017 (34) | Italy | 1 | 41 | F | Hyaluronic acid | Melanoses | Lower lip | n.d. |
| 16 | Ehsani A.H., 2019 (35) | Iran | 2 | 25; 28 |
F | vitamin E | Lipogranuloma | Both lips | 1 |
| 17 | Kaczorowski M., 2020 (36) | Poland | 1 | 52 | F | Hyaluronic acid | Granulomatous foreign body reaction | Buccal mucosa | 24 |
| 18 | Wege J, 2021 (37) | UK | 1 | 27 | F | Hyaluronic acid | Lymphangioma | Upper lip | 12 |
| 19 | Scarano A., 2023 (38) | Italy | 1 | 53 | F | Hyaluronic acid | Granulomatous foreign body reaction | Lower lip | 120 |
a
Study included 2 cases, but only 1 localized on the lips.
b
Study included 15 cases, but only 9 localized on the lips.