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. 2024 Sep 7;300(10):107750. doi: 10.1016/j.jbc.2024.107750

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Crown Copyright © 2024 Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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NanH has an additional +1 subsite.A, secondary structure of NanH_GH33 (blue) in complex with SAc₃LacNAc (green sticks) showing the three extended loops surrounding the active site (pink). Y310 that packs against the galactose in the +1 subsite is shown as sticks. B, surface of NanH_GH33 showing the packing of the extended glycan against the extended surface of Y310 and the loops. C, NanI_GH33 (shown as a surface) overlapped with NanH_GH33 in complex with SAc₃LacNAc (as shown in panel A). D, NanJ_GH33 (shown as a surface) overlapped with NanH_GH33 in complex with SAc₃LacNAc (as shown in panel A). Surfaces are shown as color ramped from red to white to blue as by their predicted negative to neutral to positive charge.