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. 2024 Sep 7;300(10):107750. doi: 10.1016/j.jbc.2024.107750

Figure 4.

Figure 4

Structures of NanI, NanJGH33, and NanHGH33. A, a comparison of the catalytic domains of NanJGH33 (orange), NanHGH33 (blue), and NanI (yellow, PDB code: 2VK5). The insertion loop in NanJGH33 and NanI is highlighted in light orange/yellow. B, Neu5Ac complexed in the −1 binding site of NanJGH33 and NanI (PDB code: 2BF6). C, Neu5Ac complexed in the −1 binding site of NanHGH33 and NanI (PDB code: 2BF6). The distance cutoff for H-bonds, shown as dashed black lines, was chosen as 3.3 Å. Neu5Ac, N-acetylneuraminic acid; PDB, Protein Data Bank.