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. 2024 Sep 7;300(10):107750. doi: 10.1016/j.jbc.2024.107750

Figure 6.

Figure 6

NanIGH33in complex with Neu5Gc reveals a “Gc” binding pocket.A, solvent accessible surface of the crystal structure of NanIGH33 in complex with Neu5Gc. B, solvent accessible surface of the −1 subsite in the crystal structure of NanJGH33 Neu5Ac complex and (C) the crystal structure of NanHGH33 Neu5Ac complex. The pocket accommodating the glycerol group of Neu5Gc is highlighted in each panel. The red sphere in each panel is the conserved water molecule that occupies a putative 8-O-Ac binding pocket. Neu5Ac, N-acetylneuraminic acid; Neu5Gc, N-glycolylneuraminic acid.