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. 2024 Oct 23;634(8036):1211–1220. doi: 10.1038/s41586-024-08070-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a) Malinois improves identification of CREs with K562-specific activity and synthetic sequence generation enables creation of CREs with enhanced functions. Distribution of MPRA-measured K562-specific activity in various candidate CRE groups. Green and aquamarine lines indicate median MinGap of DHS-natural and Malinois-natural candidates respectively. Sequences with a replicate log₂FC standard error greater than 1 in any cell type were omitted from the plots. Boxes demarcate the 25th, 50th, and 75th percentile values, while whiskers indicate the outermost point within 1.5 times the interquartile range from the edges of the boxes. Number of sequences left to right n = 3,729; 3,410; 3,584; 3,545; 3,738; 955; 958; 967; 958; 962. (b) Same as (a) except quantification of candidate sequences targeting HepG2. Number of sequences left to right n = 3,757; 3,727; 3,703; 3,531; 3,683; 917; 938; 961; 953; 966. (c) Same as (a) except quantification of candidate sequences targeting SK-N-SH. Number of sequences left to right n = 3,261; 3,804; 3,894; 3,868; 3,915; 978; 968; 976; 972; 972.