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. 2024 Oct 23;634(8036):1211–1220. doi: 10.1038/s41586-024-08070-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — Collection of synthetic sequences prioritized for in vivo validation. Sequences in panels (a-c) and (d-f) are expected to drive expression in liver and neurons, respectively. Left column: Nucleotide sequence, motif matches, and contribution score tracks for each candidate. Right column: Bar plots of empirical MPRA signal (left y-axis) in K562 (teal), HepG2 (gold), and SK-N-SH (red) as well as aggregated Enformer predictions (right y-axis) of epigenetic signals reflecting transcriptional activation in mouse spleen (dim teal), liver (dim gold), neural tissue (dim red), heart, intestine, kidney, limb buds, lung, pancreas, and stomach.