Extended Data Fig. 6. High impact non-coding variant in the LDHB locus.

a, Regional association plot for the LDHB locus. The horizontal axis indicates genomic coordinates, and the vertical axis shows the negative log₁₀ P-value. b, Beta estimate, PPI, and allele frequency in the global population of rs542962114. c, Schematic representation of LDHB locus where rs542962114 is located. The horizontal axis shows the genomic coordinate. d, Machine learning derived feature for rs542962114 (Methods). PPI, posterior probability of inclusion; AAF, alternate allele frequency; BBJ, Biobank Japan; EAS, East Asian; AFR, African; AMR, Admixed American; ASJ, Ashkenazi Jewish; FIN, Finnish; NFE, non-Finnish European; OTH, others. AAF was obtained from the gnomAD dataset. The numbers of individuals included in the association analysis are found in Supplementary Table 1, and abbreviations for phenotypes are found in Supplementary Table 2.