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. 2024 Oct 3;56(10):2027–2035. doi: 10.1038/s41588-024-01913-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 9 — a, Enrichment of causal eQTL variants in GTEx for variants with high PPI in the current study. The fine-mapped eQTL variants are obtained from results using DAP-G as a representative. Each point and error bar shows the enrichment odds ratios and 95% confidence interval. The odds ratio and its 95% confidence interval were estimated by Fisher’s exact test. The numbers of variants included in the analysis are shown after the PPI bins. b, Comparable distribution of credible set sizes between UKB and BBJ. c, Enhanced enrichment of causal variants in functional annotations in high PPI variants and comparable enrichment for functional annotations between Japanese data and UKB data. Each point and error bar shows the enrichment odds ratios and 95% confidence interval. The odds ratio and its 95% confidence interval were estimated by Fisher’s exact test. The numbers of variants included in the analysis are shown after the variant annotations (BBJ/UKB). d, Correlations of functional enrichment between UK and Japan in both sets of variants with different PPI. PPI, posterior probability of inclusion; BBJ, Biobank Japan; UKB UK Biobank; UTR, untranslated region; TF, transcription factor.