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. 2024 Oct 3;56(10):2027–2035. doi: 10.1038/s41588-024-01913-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 2 — a, Single-cell expression status of TNFRSF17 in 31,021 human peripheral blood mononuclear cells. In the right panel, TNFRSF17-expressing cells are highlighted. Color intensity indicates TNFRSF17 expression level. The left panel shows the cell population. Data were obtained from Single Cell Portal (Single Cell Comparison: PBMC data). b,c, Muscle-specific expression of RYR1 (b) and CACNA1S (c). Numbers of samples are shown after the organ name. Violin plots show distribution of gene expression in TPM. Boxplot shows the median value as the centerline; box boundaries show the first and third quartiles and whiskers extending 1.5 times the interquartile range. d, Strong association of CACNA1S with creatine kinase (CK) levels. Regional plot, beta estimate, PPI, and AAF of rs3850625 are indicated. The numbers of individuals included in the analysis are shown after the trait names. PPI, posterior probability of inclusion; AAF, alternate allele frequency; BBJ, Biobank Japan; EAS, East Asian; AFR, African; AMR, Admixed American; ASJ, Ashkenazi Jewish; FIN, Finnish; NFE, non-Finnish European; OTH, others. AAF was obtained from the gnomAD dataset. The numbers of individuals included in the association analysis are found in Supplementary Table 1.