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. 2024 Oct 15;51:102147. doi: 10.1016/j.tranon.2024.102147

Table 4.

List of recent findings on in situ CAR cell therapy. Updated till 07/04/2024.

Reference State Target Antigen Vehicle Target Cell
Magee et al. [62]. Preclinical Lipid nanoparticle T cell
Parker et al. [108]. Preclinical CD20 Lentiviral vector T cell
Mei et al. [109]. Preclinical CD3 Lentiviral vector T cell
Krotova et al. [110]. Preclinical CD19 Lentiviral vector T cell
Andorko et al. [111]. Preclinical CD20 Lentiviral vector T cell and NK cell
Beltran-Garcia et al. [112]. Preclinical Lipid nanoparticles and virus-like particles T cell, NK cell and macrophage
Green et al. [113]. Preclinical CD19 Fusosomes (viral vectors pseudotyped with modified paramyxovirus envelopes targeting specific cell types) T cell
Rurik et al. [114]. Preclinical CD5 Lipid nanoparticle T cell
Smith et al. [115]. Preclinical CD3 PBAE polymers with PGA coating T cell
Parayath et al. [116]. Preclinical CD8 PBAE polymers with PGA coating T cell