Table 3.

Univariate and multivariate cox regression to analyze the overall survival of patients with colorectal neuroendocrine tumors

Variables	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
Age, years
< 80	1	Reference		1	Reference
≥ 80	3.45	2.77, 4.31	< 0.001	2.89	2.30, 3.62	< 0.001
Sex
Male	1	Reference		1	Reference
Female	0.65	0.55, 0.77	< 0.001	0.50	0.41, 0.60	< 0.001
Year of diagnosis
2000–2006	1	Reference		1	Reference
2007–2013	1.22	0.95, 1.56	0.121	1.36	0.96, 1.75	0.116
2014–2020	1.47	1.10, 1.96	0.009	1.25	0.93, 1.68	0.134
Grade
I	1	Reference		1	Reference
II	1.39	1.30, 1.50	< 0.001	1.46	1.36, 1.59	< 0.001
T stage
T1	1	Reference		–	–	–
T2	1.49	0.91, 2.45	0.116	–	–	–
T3	0.96	0.54, 1.71	0.895	–	–	–
Marital status
Married	1	Reference		1	Reference
Unmarried	1.40	1.18, 1.66	< 0.001	1.56	1.28, 1.89	< 0.001
Chemotherapy
Yes	1	Reference		1	Reference
No/Unknown	2.77	1.52, 5.04	< 0.001	1.40	0.75, 2.60	0.288
Treatment
ET	1	Reference		1	Reference
SR	2.06	1.73, 2.46	< 0.001	1.89	1.57, 2.27	< 0.001

ET endoscopic therapy, SR surgical resection, HR hazard ratios, CI confidence interval

Bold values indicate P < 0.05