Table 4.
Univariate and multivariate cox regression to analyze the cancer specific survival of patients with colorectal neuroendocrine tumors
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age, years | ||||||
| < 80 | 1 | Reference | 1 | Reference | ||
| ≥ 80 | 4.10 | 2.58, 6.50 | < 0.001 | 2.89 | 1.80, 4.64 | < 0.001 |
| Sex | ||||||
| Male | 1 | Reference | 1 | Reference | ||
| Female | 0.65 | 0.43, 0.96 | 0.030 | 0.43 | 0.28, 0.67 | < 0.001 |
| Year of diagnosis | ||||||
| 2000–2006 | 1 | Reference | – | – | – | |
| 2007–2013 | 0.70 | 0.38, 1.28 | 0.251 | – | – | – |
| 2014–2020 | 1.22 | 0.67, 2.23 | 0.522 | – | – | – |
| Grade | ||||||
| I | 1 | Reference | – | – | – | |
| II | 0.86 | 0.53, 1.40 | 0.543 | – | – | – |
| T stage | ||||||
| T1 | 1 | Reference | – | – | – | |
| T2 | 0.00 | 0.00, Inf | 0.994 | – | – | – |
| T3 | 1.43 | 0.45, 4.53 | 0.539 | – | – | – |
| Marital status | ||||||
| Married | 1 | Reference | 1 | Reference | ||
| Unmarried | 1.74 | 1.18, 2.58 | 0.006 | 2.26 | 1.46, 3.51 | < 0.001 |
| Chemotherapy | ||||||
| Yes | 1 | Reference | 1 | Reference | ||
| No/Unknown | 3.58 | 1.13, 11.31 | 0.030 | 1.59 | 0.49, 5.09 | 0.438 |
| Treatment | ||||||
| ET | 1 | Reference | 1 | Reference | ||
| SR | 5.04 | 3.32, 7.67 | < 0.001 | 4.82 | 3.14, 7.40 | < 0.001 |
ET endoscopic therapy, SR surgical resection, HR hazard ratios, CI confidence interval
Bold values indicate P < 0.05