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. 2024 Oct 30;7:1295. doi: 10.1038/s42003-024-06281-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Three representative colon mIF images with labeled tissue domains (α = 0.02). b Estimated number of tissue domains in adjusted inertia plot. c Domain profile describing marker composition of each TD. d Scatter plot for proportion for tissue domains that are significantly associated with pre-cancer subtypes. e Scatter plot for the log of size of maximum connected components for tissue domains that are significantly associated with pre-cancer subtypes. *Signifies a p value < 0.05 and ****signifies a p value < 0.0001.