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. 2024 Oct 30;8:246. doi: 10.1038/s41698-024-00742-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — A Representative RNA in situ hybridization (ISH) images of Ccl3 in tumor sections from mice bearing FC1245, RC416, CR705, B6KPC, DT4313 and PAN610 cells. Scale bar: 150 μm. B Plasma levels of Ccl3 were measured in C57BL/6 J mice bearing orthotopic PDAC tumors from 6 different murine PDAC cell lines using Enzyme-Linked Immunosorbent Assay (ELISA). Data are expressed as mean ± s.d. (n = 6). C Median overall survival (mOS) of C57BL/6 J mice bearing orthotopic PDAC tumors (n = 6). D, E Flow cytometry analysis of Cd45⁺/Cd11b⁺/F4/80⁺ tumor-associated macrophages (TAMs) (D) and their M2 (Cd45⁺/Cd11b⁺/F4/80⁺/Cd204⁺/Cd86⁻)/M1(Cd45⁺/Cd11b⁺/F4/80⁺/Cd204⁻/Cd86⁺) ratio (E) in FC1245, RC416, CR705, B6KPC, DT4313 and PAN610 tumor samples. Data are expressed as mean ± s.d. (n = 4). F Representative images of FC1245, RC416, CR705, B6KPC, DT4313 and PAN610 tumors stained with E-cadherin, vimentin, gata-6, pan-cytokeratin antibodies and H&E. Scale bar = 60 μm. G–J Quantification of paraffin sections from orthotopic murine PDAC tumors stained as indicated in (F). Data are expressed as mean ± s.d. (n = 4).