Table 2. Selectivity index for hCA I/II inhibition over hCA IX/XII for novel 1,2,3-triazolyloxime substituted-1,2,3-triazolyl sulfonamides (7a–o).
| Compounds ID | S I a | |||
|---|---|---|---|---|
| hCA IX/I | hCA IX/II | hCA XII/I | hCA XII/II | |
| 7a | 9.8 | 10.2 | 3.1 | 3.3 |
| 7b | 4.1 | 7.1 | 4.8 | 8.2 |
| 7c | 4.6 | 4.1 | 3.7 | 3.3 |
| 7d | 9.2 | 12.1 | 8.8 | 11.6 |
| 7e | 8.8 | 8.3 | 3.6 | 3.4 |
| 7f | 3.1 | 3.7 | 4.0 | 4.9 |
| 7g | 3.6 | 3.7 | 4.0 | 4.0 |
| 7h | 4.6 | 5.6 | 4.9 | 6.0 |
| 7i | 4.7 | 5.3 | 3.3 | 3.7 |
| 7j | 2.5 | 2.8 | 2.0 | 2.2 |
| 7k | 2.4 | 1.9 | 3.0 | 2.4 |
| 7l | 3.5 | 3.5 | 2.6 | 2.5 |
| 7m | 3.6 | 3.9 | 1.9 | 2.0 |
| 7n | 1.7 | 1.8 | 2.5 | 2.5 |
| 7o | 0.9 | 0.7 | 2.4 | 1.8 |
| AAZb | 1.0 | 1.3 | 0.7 | 1.0 |
a
Selectivity index.
b
Acetazolamide.