Fig. 1.

Illustrated workflow showing processing of ADNI 3 T MPRAGE data for hypothalamic volumetry as well as structural covariance analysis with SPM12 software and the CAT12 toolbox implemented in SPM12. ADNI Alzheimer’s disease neuroimaging initiative, ACPC anterior commissure posterior commissure, CAT12 computational anatomy toolbox, CTH cortical thickness, GM-TPM gray matter tissue probability map, GMV gray matter volume, HTH hypothalamus, ROI region of interest, SBM source-based morphometry, SPM statistical parametric mapping, VBM voxel-based morphometry, WMV white matter volume.