Table 1.
Characteristics of studies investigating survival outcomes in early-onset oesophageal adenocarcinoma patients
|
Ref.
|
Publication year
|
Country
|
Study design
|
No. of cases
|
No. of cases < 50 (%)
|
Recruitment period
|
Age categories (years)
|
Stage
|
Follow-up (Y/N)
|
Specific survival outcome
|
Confounders considered
|
| Boys et al[16] | 2015 | United States | Retrospective cohort | 772 | 42 (5) | 1990-2013 | < 40, > 40 | I-IV | Y | Median overall survival | Sex, race, staging, year of diagnosis |
| Kolb et al[17] | 2020 | United States | Population- based Register | 114123 | 10271 (9) | 2000-2017 | < 50, 50-69, > 70 | I-IV | Y | Median survival, HR of death | Treatment, staging, race |
| Codipilly et al[20] | 2021 | United States | Population based register | 25813 | 2183 (8) | 1975-2011 | < 50, 50-69, > 70 | I-IV | Y | Overall 5 year survival | Sex, race, staging, year of diagnosis |
| Xie et al[21] | 2017 | Sweden | Population- based cohort | 5140 | 212 (4.1) | 1961-2014 | < 50, 50-59, 60-69, 70-79, > 80 | Not recorded | Y | HR of death | Sex |
| Haiyu et al[22] | 2019 | United States | Population-based register | 16474 | Crude number not reported | 1984-2013 | 20-44, 45-54, 55-64, 65-74, > 75 | Not recorded | Y | 5-year relative survival | Sex, Socio-economic status, race |
| Hashemi et al[23] | 2009 | United States | Consecutive case series | 242 | 31 (12.8) | 1994-2004 | < 50, > 50 | 0-IV | N | Median survival | Sex, family history |
| Portale et al[24] | 2004 | United States | Consecutive case series | 263 | 32 (12.1) | 1992-2002 | < 50, > 50 | I-III | N | 5-year survival rates | |
| Sawas et al[14] | 2019 | United States | Single centre retrospective study |
682 | 105 (15.4) | 2009-2012 | < 50, 51-70, > 70 | I-IV | N | Mean survival, 5-year survival rates, HR of death | Sex, staging, intestinal metaplasia, Charlson comorbidity index |
| Strauss et al[25] | 2020 | United States | Single centre retrospective study |
630 | 65 (10.3) | 1991-2018 | < 50, > 50 | I-IV | Y | Overall survival, HR of death | Sex, race, pathology grade |
| van Nistelrooij et al[15] | 2014 | Netherlands | Population-based register | 13331 | 1466 (10.9) | 2000-2011 | < 50, > 50 | I-IV | Y | Median overall survival, 5-year overall survival | Sex, staging |
| Yang et al[26] | 2016 | United States | Population-based register | 2601 | 94 (3.6) | 1988-2011 | < 45, 45-59, 60-74, > 75 | I-III | Y | HR of death | Sex, race, lymph nodes examined |
HR: Hazard ratio; Y: Yes; N: No.