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. Author manuscript; available in PMC: 2024 Oct 31.
Published in final edited form as: Chem Biol Interact. 2016 Apr 7;259(Pt B):133–141. doi: 10.1016/j.cbi.2016.04.002

Table 4.

Exploring the Role of the Aniline Amine Group. Ratio (spontaneous/compound) of half-times (t1/2) of reactivation for compounds (1mM) with RHuAChE after inhibition by the indicated agent.

graphic file with name nihms-2023525-t0025.jpg graphic file with name nihms-2023525-t0026.jpg graphic file with name nihms-2023525-t0027.jpg graphic file with name nihms-2023525-t0028.jpg Inhibition of RHuAChE @ 1mM Hammett Values[23] (σp)
GB GF VX VR
1 graphic file with name nihms-2023525-t0029.jpg 361* (158–824) 164* (97.3–277) 1,069* (393.6–2911) 14,723* (6.46–33,573,761) 60% (± 1) −0.66
11 graphic file with name nihms-2023525-t0030.jpg 6.15* (4.98–7.60) 3.07* (2.92–3.23) 16.5* (13.0–20.8) 32.7* (24.1–44.4) 0% (± 6) −0.83
12 graphic file with name nihms-2023525-t0031.jpg 3.85* (3.22–4.61) 1.72* (1.67–1.77) 6.95* (5.03–9.59) 19.0* (15.2–23.7) 0% (± 5) 0.00
13 graphic file with name nihms-2023525-t0032.jpg 1.43* (1.37–1.50) 1.09 (0.80–1.49) 1.24 (0.99–1.56) 1.65* (1.54–1.78) 35% (± 4) N/A
14 graphic file with name nihms-2023525-t0033.jpg 1.70* (1.40–2.06) 1.30 (0.90–1.89) 1.61* (1.17–2.21) 1.59* (1.35–1.87) 43% (± 11) N/A