Fig. 2.

Descriptive discriminant analysis of serum glycogen storage disease type Ia (GSDIa) lipidome. A: Differential segregation (components 1 and 2: 7.2% and 12.5%, respectively) was observed in the serum lipid content of patients with GSDIa and healthy and hypercholesterolemic controls. B: Discriminant features were identified according to the variable importance in projection (VIP) score, and the 20 most important molecules with VIP scores >2.0 were reported. Box color intensity represents the relative abundance for each group. The concentrations of the identified lipids were normalized, log(10) transformed, and Pareto scaled. C: Total lipid content, expressed as the sum of lipid quantity within a specific lipid class (mean $\pm$ SEM) in patients with GSDIa (dark blue) and healthy (light blue) and hypercholesterolemic controls (gray). Ceramides reflect those of Supplemental Table S2 with sphingosine and sphingadiene; hydroxyceramides those with sphingosine and sphinganine.