Fig. 10. Evaluation of the therapeutic properties of Ru(II)-OH, NP2, or NP4 (2 mg Ru/kg) upon intravenous injection in the PDXOS model.
a Schematic illustration of the establishment of PDX model as well as the subsequent treatment schedule. b, c Tumor growth inhibition curves upon treatment. n = 5 mice. d Body weight upon treatment. n = 5 mice. e Photograph of tumors isolated from mice after different treatments. f Average tumor weight of the mice 15 days after treatment. n = 5 mice. g H&E and TUNEL stain of the tumor tissues. Data are presented as mean ± standard deviation. n = 5 mice. Data are presented as mean ± SD. Statistical significance between every two groups was calculated by T-test, the statistical test used was two-sided. Figure 10a Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.