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. 2024 Oct 31;15:9405. doi: 10.1038/s41467-024-53646-y

Fig. 7. The biosafety, biodistribution, and anti-tumor effect of NP4 in orthotopic K7M2 osteosarcoma model.

Fig. 7

a Schematic treatment schedule. b Time-dependent imaging of the animal model upon injection of NP4-Cy7.5 (H heart, Li liver, S spleen, L lung, K kidney, T tumor). c Quantification from (b) (n = 5 mice). d Biodistribution inside the animal model 48 h after the injection of NP4-Cy7.5 (n = 5 mice). e Bioluminescence imaging of orthotopic K7M2 osteosarcoma model after receiving PBS, Ru(II)-OH, NP2, and NP4 in vivo (n = 5 mice). f Tumor tissue slices were stained with Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) (green) and DAPI (blue) following different treatments. Figure 7a Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.