Figure 4.

Histological slides showing knee joint integrity. (A) Severe lesions commonly seen in the femur of rats in the nonexercised/sedentary groups (Sed = Chow+Sed and HFS+Sed). OA femur score = 33 (maximum = 36). (B) Exemplar joint showing healthy cartilage and bone of the rats subjected to aerobic or resistance exercise (EXE = HFS+Aer and HFS+Res). OA femur score = 2 (maximum = 36). The black arrow indicates a severe bone lesion and bone degeneration associated with a collapse of the adjacent cartilage. OA = osteoarthritis; HFS = high fat/high sucrose; HFS+Aer = HFS diet and subjected to aerobic exercise; HFS+Res = HFS diet and subjected to resistance exercise.