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. 2023 Feb 9;17:e01. doi: 10.15420/usc.2022.22

Table 1: Cardiotoxicities Associated with Commonly Used Antipsychotic Medications.

Drug class Drugs Tachycardia Bradycardia Hypotension Hypertension QTc prolongation Arrhythmias and conduction blocks VTE Cardiomyopathy Hyperlipidemia
Typical antipsychotic Chlorpromazine - - +++ + +++ + + - +
Fluphenazine - - + - + + + - +
Haloperidol + - + - ++ - - - +
Loxapine + - ++ + - - - - +
Molindone + - + - - - - - +
Perphenazine + + ++ + - - + + +
Pimozide - - + + ++ - + - +
Thioridazine - - +++ - ++ + - - +
Thiothixene + - + - - - - - +
Trifluoperazine + - + - - + + - +
Atypical antipsychotic Aripiprazole + + + ++ - + + - +
Asenapine ++ + ++ ++ + + - - ++
Brexpiprazole - + + + - + - - +
Cariprazine ++ + + ++ - + + - +
Clozapine +++ - +++ +++ ++ + + ++ +++
lloperidone +++ - +++ - + + - - +
Lumateperone - - + - - - - - +
Lurasidone ++ - + ++ + + - ++
Olanzapine ++ + ++ ++ ++ + - +++
Paliperidone +++ ++ ++ ++ + ++ + - ++
Pimavanserin - - ++ - + - - - +
Quetiapine +++ - ++ - ++ + - + +++
Resperidone ++ - ++ ++ ++ + - - +
Ziprasidone ++ - ++ ++ +++ + + - +

VTE = venous thromboembolism. The following ore indicators of the association with the specific cordiotoxicities: -= no association; + = weak association; ++ = significant association; +++ = strong association.