Table 1: Cardiotoxicities Associated with Commonly Used Antipsychotic Medications.
Drug class | Drugs | Tachycardia | Bradycardia | Hypotension | Hypertension | QTc prolongation | Arrhythmias and conduction blocks | VTE | Cardiomyopathy | Hyperlipidemia |
---|---|---|---|---|---|---|---|---|---|---|
Typical antipsychotic | Chlorpromazine | - | - | +++ | + | +++ | + | + | - | + |
Fluphenazine | - | - | + | - | + | + | + | - | + | |
Haloperidol | + | - | + | - | ++ | - | - | - | + | |
Loxapine | + | - | ++ | + | - | - | - | - | + | |
Molindone | + | - | + | - | - | - | - | - | + | |
Perphenazine | + | + | ++ | + | - | - | + | + | + | |
Pimozide | - | - | + | + | ++ | - | + | - | + | |
Thioridazine | - | - | +++ | - | ++ | + | - | - | + | |
Thiothixene | + | - | + | - | - | - | - | - | + | |
Trifluoperazine | + | - | + | - | - | + | + | - | + | |
Atypical antipsychotic | Aripiprazole | + | + | + | ++ | - | + | + | - | + |
Asenapine | ++ | + | ++ | ++ | + | + | - | - | ++ | |
Brexpiprazole | - | + | + | + | - | + | - | - | + | |
Cariprazine | ++ | + | + | ++ | - | + | + | - | + | |
Clozapine | +++ | - | +++ | +++ | ++ | + | + | ++ | +++ | |
lloperidone | +++ | - | +++ | - | + | + | - | - | + | |
Lumateperone | - | - | + | - | - | - | - | - | + | |
Lurasidone | ++ | - | + | ++ | + | + | - | ++ | ||
Olanzapine | ++ | + | ++ | ++ | ++ | + | - | +++ | ||
Paliperidone | +++ | ++ | ++ | ++ | + | ++ | + | - | ++ | |
Pimavanserin | - | - | ++ | - | + | - | - | - | + | |
Quetiapine | +++ | - | ++ | - | ++ | + | - | + | +++ | |
Resperidone | ++ | - | ++ | ++ | ++ | + | - | - | + | |
Ziprasidone | ++ | - | ++ | ++ | +++ | + | + | - | + |
VTE = venous thromboembolism. The following ore indicators of the association with the specific cordiotoxicities: -= no association; + = weak association; ++ = significant association; +++ = strong association.