Table 3.

Time measurements of active HCP time during drug preparation and administration, and time spent at the day care unit. ICI-B indicates conventional infusion of immune checkpoint inhibitors; ICI-P, immune checkpoint inhibitors administrated via an elastomeric pump

HCP Time required per task and patient time spent at the day care unit (minutes)
	ICI-B (Preparation n  = 22, Administration n  = 10)				ICI-P (Preparation n  = 10, administration n  = 12)			Incremental time (ICI-B minus ICI-P)
	Average	Median	IQR	Average		Median	IQR	Difference
Drug preparation
Collecting materials	2.23	2.18	1.83–2.60	2.13		2.02	1.92–2.57	0.10
Preparing drug	1.88	1.73	1.51–2.03	6.76		5.17	4.52–6.08	-4.88
Finishing product	0.93	0.90	0.60–1.10	1.43		1.18	1.07–1.33	-0.50
Product sign-off	0.39	0.30	0.20–0.50	0.49		0.38	0.18–0.76	-0.09
Total drug preparation active pharmacy technician time	4.94	4.53	4.11–5.56	9.68		8.25	6.67–9.60	-4.74
Total drug preparation active pharmacist time	0.39	0.30	0.20–0.50	0.49		0.38	0.18–0.76	-0.09
Drug administration
Collecting of materials	3.48	3.08	2.33–2.80	3.18		2.99	2.31–3.98	0.30
Install of intravenous access	4.39	4.61	2.18–5.89	5.07		4.02	2.53–5.94	-0.69
Pre-administration flushing	5.85	5.03	4.91–5.81	-		-	-	5.85
Post-administration flushing	5.63	5.72	5.19–5.95	-		-	-	5.63
Disconnect and dispose of materials	1.83	1.98	1.50–2.20	1.79		1.79	1.48–2.07	0.05
Time spent with patient beyond standard tasks	0.90	0.00	0.00–0.00	0.00		0.00	0.00–0.00	0.90
Total drug administration active nurse time	22.07	21.46	19.78–24.45	9.62		8.25	7.69–11.10	12.45
Patient time
Infusion time	49.40	51.00	45.50-55.25	60.83		60.50	58.75–63.25	-11.43
Time spent outside day care unit	-	-	51.50-60.25	56.25		59.00	51.50-60.25	56.25
Total treatment duration	73.30	74.50	68.50–77.00	72.50		69.00	66.00–77.00	0.80
Total chair time	73.30	74.50	68.50–77.00	16.25		15.50	13.00-18.50	57.05