Table 2.
Interaction analysis between SII and trouble sleeping in patients with nonalcoholic fatty liver disease
| SII | Trouble sleeping | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| Additive interaction | |||||||
|
Normal-level (n = 5483) |
No (n = 8073) |
Ref | Ref | Ref | |||
|
Normal-level (n = 5483) |
Yes (n = 2890) |
1.45 (1.28, 1.65) | < 0.001 | 1.40 (1.20, 1.63) | < 0.001 | 1.02 (0.84, 1.24) | 0.819 |
|
High-level (n = 5480) |
No (n = 8073) |
1.35 (1.23, 1.48) | < 0.001 | 1.32 (1.19, 1.47) | < 0.001 |
1.11 (0.96, 1.27) |
0.149 |
|
High-level (n = 5480) |
Yes (n = 2890) |
2.08 (1.84, 2.34) | < 0.001 |
2.05 (1.77, 2.36 |
< 0.001 | 1.39 (1.13, 1.63) | 0.001 |
| RERI (95% CI) |
2.28 (1.46, 3.10) |
2.07 (1.18, 2.95) | 0.41 (0.05, 0.77) | ||||
| AP (95% CI) | 0.56 (0.50, 0.62) | 0.55 (0.47, 0.62) | 0.27 (0.12, 0.41) | ||||
| SI (95% CI) | 3.83 (3.31, 4.44) | 3.86 (3.22, 4.62) | 4.17 (1.10, 15.77) | ||||
| Multiplicative interaction | |||||||
| SII × Trouble sleeping | 1.06 (0.89, 1.26) | 0.519 | 1.10 (0.90, 1.36) | 0.340 | 1.19 (0.89, 1.59) | 0.237 | |
No adjustments were made to Model 1. Model 2 is adjusted for age, sex, and ethnicity. Model 3 was adjusted for the variables in Model 2, including education, waist circumference, body mass index, marital status, smoking habits, total energy intake, alcohol intake, physical activity, ALT, AST, GGT, diabetes, hyperlipidemia, hypertension, coronary heart disease, and stroke
Abbreviations: SII: Systemic immune-inflammation index, CI: Confidence interval, RERI: Relative excess risk of interaction, AP: Attribution proportion, SI: Synergy index, OR: Odds ratio, ALT: Alanine aminotransferase, AST: Aspartate aminotransferase, GGT: Gamma-glutamyl transferase