Table 1.
Genes relevant to cAMP/PKA/CREB signaling that are differentially expressed (FDR < 0.05) in SCAN-B, TCGA and METABRIC and their fold changes in the respective datasets
| Gene | Description | Fold change in SCAN-B | Fold chnage in TCGA | Fold change in METABRIC |
|---|---|---|---|---|
| G alpha receptors | ||||
| PTGER4 | Prostaglandin E2 receptor | 1.24 | 1.38 | 1.37 |
| ADRB2 | Beta adrenergic receptor | 1.15 | 1.32 | 1.19 |
| S1PR1 | Sphingosine-1-phosphate receptor 1 | 1.33 | 1.37 | 1.24 |
| G protein subunits | ||||
| GNAS | G protein Subunit Alpha S | 0.93 | 0.77 | 0.86 |
| GNB1 | G protein Subunit Beta 1 | 0.92 | 0.83 | 0.91 |
| GNG7 | G protein Subunit Gamma 7 | 1.19 | 1.45 | 1.15 |
| GNG11 | G protein Subunit Gamma 11 | 1.26 | 1.24 | 1.40 |
| Adenylyl cyclase | ||||
| ADCY4 | Adenylate Cyclase 4 | 1.28 | 1.68 | 1.30 |
| ADCY5 | Adenylate Cyclase 5 | 1.62 | 1.53 | 1.07 |
| Phosphodiesterases | ||||
| PDE1A | Phosphodiesterase 1A | 1.34 | 1.21 | 1.39 |
| PDE2A | Phosphodiesterase 2A | 1.47 | 1.44 | 1.11 |
| PDE4B | Phosphodiesterase 4B | 1.30 | 1.32 | 1.37 |
| PDE9A | Phosphodiesterase 9A | 1.20 | 1.34 | 1.11 |
| A-kinase Anchoring Protein | ||||
| AKAP7 | A-kinase anchoring protein 7 | 1.17 | 1.17 | 1.19 |
| AKAP8 | A-kinase anchoring protein 8 | 1.04 | 1.22 | 1.08 |
| Targets for PKA Phosphorylation | ||||
| SRC | SRC Proto-oncogene | 0.90 | 0.81 | 0.87 |
| CAMK2B | Calcium/calmodulin dependent protein kinase II | 0.57 | 0.68 | 0.75 |
| PPARG | Peroxisome proliferator-activated receptor gamma | 1.38 | 1.28 | 1.55 |
| RYR3 | Ryanodine receptor 3 | 1.76 | 1.45 | 1.09 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | 1.23 | 1.39 | 1.30 |
| LIPE | Hormone sensitive lipase | 1.79 | 1.69 | 1.24 |
| DUSP6 | Dual specificity phosphatase 6 | 1.24 | 1.22 | 1.26 |
| Other related genes | ||||
| RGS2 | Regulator of G Protein Signaling 2 | 1.16 | 1.48 | 1.25 |
| RAPGEF3 | Rap Guanine Nucleotide Exchange Factor 3 | 1.25 | 1.92 | 1.21 |