Box 1.

Contraindications

CGRP mAbs	Gepants
Pregnancy and breastfeeding
Known sensitivity to drug (avoid erenumab if latex sensitivity)
Significant cardiovascular/cerebrovascular/peripheral vascular disease (including severe Raynaud’s disease) within the last 6 months
	Significant renal or liver impairment
	Certain antibiotics, certain seizure medications, and grapefruita

^a For drug interactions, please refer to the British National Formulary (or equivalent). CGRP = calcitonin gene-related peptide. mAbs = monoclonal antibodies