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Inverted coupling of BSol position and pore aperture is observed in the presence of dantrolene. A. Schematic representations of Normal and Inverted (+Dantrolene) coupling modes.
B. Neighboring BSol and SPRY domains exhibit an inverted relative domain movement when dantrolene & ATP/ADP are bound in RY12, and the pore diameters (Cα distances of I4937 in the pore) are comparable to that of open and closed channels.
