Table 3: Multiple hypothesis testing of the significant changes in epigenetic age.

Results from multiple hypothesis correction for 12 statistical tests. ∆ indicates the mean change in epigenetic age residual from before to after intervention/event. Uncorrected column has no multiple hypothesis correction. BH: Benjamini-Hochberg. An asterisk represents a significant result for that statistical test with the particular hypothesis correction method as defined by the column.

Dataset	Clock	∆	p value	Uncorrected	BH	Bonferroni
GSE184202
	Horvath SB	0.96	0.0454	*
GSE171140
	Hannum	0.70	0.0303	*
GSE63499
	Hannum	2.14	0.0352	*
E-MTAB-8956
	Hannum	−1.78	8.8e-04	*	*	*
GSE74548
	Horvath MT	−3.18	0.0111	*
GSE142536
	PCHannum	2.80	4.8e-05	*	*	*
	PCHorvath MT	1.97	9.8e-06	*	*	*
	PCHorvath SB	1.90	2.1e-05	*	*	*
	PhenoAge	2.98	5.4e-03	*	*
	PCPhenoAge	3.58	3.7e-05	*	*	*
	GrimAge	1.74	1.1e-04	*	*	*
	PCGrimAge	1.90	1.3e-05	*	*	*
	DunedinPoAm38	0.05	7.6e-06	*	*	*
	DunedinPACE	0.09	6.7e-05	*	*	*
GSE140038
	Horvath SB	−0.70	0.0409	*
	PhenoAge	1.80	0.0302	*
	PCPhenoAge	3.09	2.3e-03	*	*	*
	GrimAge	1.68	2.7e-07	*	*	*
	PCGrimAge	1.59	2.6e-04	*	*	*
	DunedinPoAm38	0.03	5.9e-03	*	*
	DunedinPACE	0.06	1.8e-07	*	*	*
E-MTAB-12527 (MED)
	PCHannum	−0.29	0.0212	*
	PCPhenoAge	−0.53	4.7e-03	*	*
	PCGrimAge	−0.25	3.1e-03	*	*	*
	DunedinPoAm38	−0.01	7.9e-03	*	*
	DunedinPACE	−0.02	0.0140	*	*
E-MTAB-12527 (green)
	PCHannum	−0.61	7.2e-03	*	*
	PCHorvath SB	−0.44	0.0465	*
	PCPhenoAge	−0.84	1.7e-03	*	*	*
	GrimAge	−0.62	3.2e-03	*	*	*
	PCGrimAge	−0.30	7.2e-03	*	*
	DunedinPoAm38	−0.02	5.1e-06	*	*	*
	DunedinPACE	−0.02	0.0101	*	*