Figure 2. KPT-330 treatment improves cognition in 5XFAD mice performing the spontaneous alternation Y maze test.

A. Wild-type and 5XFAD mice fed control chow or chow containing low or high dose of KPT-330 were subjected to novel object recognition where discrimination and B. distance were measured, C. Spontaneous alternation and D. distance traveled in a Y maze were measured in 12 months-old wild-type and 5XFAD mice treated with or without KPT-330 for 8 months, ns: not significant, *: P<0.05, **: P<0.01, n=6–12, ANOVA.