Table 1. Comparison of clinical characteristics and OCTA parameters between different WMH groups.
| Fazekas scales | P value | Scheltens scales | P value | |||
|---|---|---|---|---|---|---|
| ≤2 | >2 | ≤10 | >10 | |||
| n | 17 | 32 | 18 | 31 | ||
| Age (years) | 64.82(6.39) | 67.00(6.86) | 0.285 | 63.83(6.47) | 67.65(6.55) | 0.054 |
| Sex (male/female) | 9/8 | 15/17 | 0.686 | 8/10 | 16/15 | 0.628 |
| Hypertension (%) | 7(41.2) | 13(40.6) | 0.97 | 7(38.9) | 13(41.9) | 0.834 |
| Diabetes (%) | 1(5.9) | 8(25) | 0.1 | 1(5.6) | 8(25.8) | 0.078 |
| Hyperlipidemia (%) | 8(47.1) | 16(50) | 0.845 | 10(55.6) | 14(45.2) | 0.483 |
| Heart diseases (%) | 1(5.9) | 2(6.3) | 0.959 | 1(5.6) | 2(6.5) | 0.9 |
| Present smokers (%) | 3(17.6) | 7(21.9) | 0.727 | 3(16.7) | 7(22.6) | 0.62 |
| Present drinkers (%) | 3(17.6) | 4(12.5) | 0.624 | 2(11.0) | 5(16.1) | 0.628 |
| BMI | 23.27(3.12) | 23.19(3.14) | 0.938 | 23.04(3.14) | 23.31(3.12) | 0.776 |
| MoCA | 26.00(6.25) | 27.00(4.00) | 0.709 | 26.00(5.50) | 27.00(4.00) | 0.755 |
| Eyesight | 1.000(0.375) | 0.800(0.450) | 0.229 | 1.000(0.350) | 0.775(0.463) | 0.245 |
| IOP | 13.88(2.43) | 14.15(3.53) | 0.479 | 13.85(2.63) | 14.28(3.43) | 0.578 |
| Ocular axis | 23.88(0.89) | 23.93(1.32) | 0.884 | 23.75(1.01) | 24.00(1.27) | 0.469 |
| Vessel density | ||||||
| Peripapillary | ||||||
| Whole | 17.55(2.00) | 16.75(2.35) | 0.148 | 17.55(2.23) | 16.65(2.30) | 0.051 |
| Inner ring | 18.60(3.05) | 16.88(2.30) | 0.03 | 18.39(2.89) | 16.87(2.16) | 0.019 |
| Temporal | 18.70(3.69) | 16.50(3.75) | 0.04 | 18.70(3.73) | 16.38(3.70) | 0.017 |
| Superior | 18.95(1.83) | 18.00(2.80) | 0.007 | 18.90(1.70) | 17.95(2.85) | 0.007 |
| Nasal | 17.23(5.28) | 16.60(4.25) | 0.225 | 17.35(4.75) | 16.38(4.38) | 0.241 |
| Inferior | 18.68(2.18) | 17.70(2.50) | 0.058 | 18.95(2.28) | 17.45(2.48) | 0.028 |
| Outer ring | 17.78(2.81) | 17.20(2.99) | 0.392 | 18.21(2.86) | 17.19(3.01) | 0.112 |
| Temporal | 18.63(2.69) | 17.65(2.60) | 0.276 | 18.70(2.13) | 17.40(2.86) | 0.097 |
| Superior | 18.25(1.96) | 18.00(2.70) | 0.375 | 18.35(1.95) | 18.00(2.76) | 0.268 |
| Nasal | 16.70(3.70) | 16.30(4.35) | 0.574 | 16.73(3.41) | 16.10(4.45) | 0.374 |
| Inferior | 18.55(2.83) | 18.35(2.80) | 0.369 | 19.05(2.63) | 17.88(2.83) | 0.129 |
| Macula | ||||||
| Whole | 13.55(4.75) | 13.00(5.30) | 0.763 | 14.13(5.54) | 12.73(4.16) | 0.537 |
| Inner ring | 13.01(3.82) | 13.25(5.89) | 0.67 | 13.38(4.31) | 13.01(5.70) | 0.413 |
| Temporal | 13.40(5.64) | 12.30(6.80) | 0.849 | 14.15(4.93) | 11.68(6.38) | 0.203 |
| Superior | 12.65(4.21) | 12.90(6.55) | 0.814 | 12.95(5.03) | 12.83(6.38) | 0.394 |
| Nasal | 12.20(6.08) | 14.70(7.20) | 0.24 | 12.53(6.04) | 12.63(6.79) | 0.949 |
| Inferior | 12.35(2.98) | 12.79(4.90) | 0.741 | 13.20(4.53) | 12.73(5.34) | 0.561 |
| Outer ring | 14.79(4.41) | 13.93(4.80) | 0.889 | 15.40(4.39) | 13.68(4.84) | 0.393 |
| Temporal | 13.05(4.60) | 12.28(7.40) | 0.628 | 14.10(4.73) | 12.05(7.63) | 0.228 |
| Superior | 15.15(4.84) | 14.18(4.31) | 0.827 | 15.50(5.28) | 13.65(3.43) | 0.375 |
| Nasal | 16.05(3.73) | 16.55(3.88) | 0.608 | 17.08(4.44) | 16.33(4.06) | 0.884 |
| Inferior | 13.98(2.67) | 13.70(3.73) | 0.789 | 14.70(4.33) | 13.28(5.20) | 0.321 |
| Perfusion density | ||||||
| Peripapillary | ||||||
| Whole | 0.442(0.055) | 0.420(0.067) | 0.178 | 0.444(0.061) | 0.418(0.064) | 0.044 |
| Inner ring | 0.479(0.089) | 0.443(0.068) | 0.057 | 0.476(0.083) | 0.439(0.064) | 0.031 |
| Temporal | 0.449(0.077) | 0.392(0.090) | 0.036 | 0.442(0.081) | 0.392(0.093) | 0.018 |
| Superior | 0.500(0.059) | 0.476(0.073) | 0.029 | 0.501(0.058) | 0.473(0.080) | 0.017 |
| Nasal | 0.469(0.116) | 0.452(0.133) | 0.302 | 0.472(0.110) | 0.451(0.134) | 0.223 |
| Inferior | 0.498(0.050) | 0.470(0.077) | 0.058 | 0.499(0.053) | 0.470(0.078) | 0.034 |
| Outer ring | 0.450(0.073) | 0.430(0.088) | 0.439 | 0.459(0.084) | 0.429(0.079) | 0.109 |
| Temporal | 0.455(0.066) | 0.427(0.069) | 0.23 | 0.457(0.054) | 0.423(0.074) | 0.086 |
| Superior | 0.467(0.042) | 0.473(0.080) | 0.582 | 0.468(0.042) | 0.467(0.077) | 0.319 |
| Nasal | 0.425(0.102) | 0.408(0.120) | 0.716 | 0.426(0.103) | 0.405(0.115) | 0.289 |
| Inferior | 0.468(0.071) | 0.463(0.079) | 0.575 | 0.479(0.068) | 0.451(0.078) | 0.138 |
| Macula | ||||||
| Whole | 0.327(0.124) | 0.312(0.137) | 0.738 | 0.344(0.148) | 0.304(0.107) | 0.53 |
| Inner ring | 0.302(0.095) | 0.306(0.154) | 0.629 | 0.315(0.106) | 0.299(0.141) | 0.425 |
| Temporal | 0.292(0.080) | 0.276(0.126) | 0.651 | 0.320(0.121) | 0.268(0.168) | 0.153 |
| Superior | 0.300(0.101) | 0.296(0.162) | 0.796 | 0.306(0.118) | 0.295(0.151) | 0.382 |
| Nasal | 0.284(0.136) | 0.340(0.180) | 0.203 | 0.289(0.148) | 0.288(0.188) | 0.907 |
| Inferior | 0.285(0.074) | 0.300(0.119) | 0.641 | 0.313(0.105) | 0.294(0.130) | 0.594 |
| Outer ring | 0.364(0.111) | 0.334(0.129) | 0.99 | 0.377(0.117) | 0.328(0.132) | 0.421 |
| Temporal | 0.315(0.119) | 0.291(0.197) | 0.695 | 0.340(0.117) | 0.285(0.192) | 0.25 |
| Superior | 0.376(0.120) | 0.346(0.119) | 0.991 | 0.385(0.131) | 0.322(0.100) | 0.381 |
| Nasal | 0.386(0.095) | 0.389(0.110) | 0.572 | 0.413(0.114) | 0.386(0.124) | 0.904 |
| Inferior | 0.339(0.071) | 0.331(0.099) | 0.796 | 0.370(0.105) | 0.315(0.147) | 0.295 |
| FAZ area (mm2) | 0.234(0.078) | 0.223(0.082) | 0.657 | 0.233(0.079) | 0.215(0.096) | 0.456 |
| FAZ perimeter(mm) | 2.02(0.32) | 1.94(0.38) | 0.495 | 2.02(0.37) | 1.95(0.51) | 0.33 |
| FAZ circularity | 0.695(0.028) | 0.703(0.044) | 0.486 | 0.703(0.021) | 0.703(0.076) | 0.764 |
BMI: Body Mass Index; MoCA: Montreal Cognitive Assessment; IOP: intra-ocular pressure; FAZ: Foveal Avascular Zone