Table 3. Comparison of clinical characteristics and OCTA parameters in DWMH.
| Fazekas scales | P value | Scheltens scales | P value | |||
|---|---|---|---|---|---|---|
| ≤1 | >1 | ≤8 | >8 | |||
| n | 24 | 25 | 23 | 26 | ||
| Age (years) | 65.08(5.42) | 67.36(7.71) | 0.239 | 63.57(6.12) | 68.62(6.42) | 0.002 |
| Sex (male/female) | 11/13 | 13/12 | 0.666 | 12/11 | 12/14 | 0.674 |
| Hypertension (%) | 9(37.5) | 11(44) | 0.644 | 8(34.8) | 12(46.2) | 0.419 |
| Diabetes (%) | 1(4.2) | 8(32) | 0.012 | 2(8.7) | 7(26.9) | 0.1 |
| Hyperlipidemia (%) | 12(50) | 12(48) | 0.889 | 13(56.5) | 11(42.3) | 0.321 |
| Heart diseases (%) | 1(4.2) | 2(8) | 0.576 | 1(4.3) | 2(7.7) | 0.626 |
| Present smokers (%) | 3(12.5) | 7(28) | 0.178 | 5(21.7) | 5(19.2) | 0.828 |
| Present drinkers (%) | 3(12.5) | 4(16) | 0.726 | 3(13.0) | 4(15.4) | 0.815 |
| BMI | 22.90(2.77) | 23.52(3.41) | 0.499 | 23.20(2.92) | 23.23(3.30) | 0.252 |
| MoCA | 27.00(5.00) | 27.00(4.00) | 0.486 | 26.50(4.25) | 27.00(4.50) | 0.880 |
| Eyesight | 0.800(0.400) | 0.800(0.463) | 0.899 | 1.000(0.400) | 0.775(0.463) | 0.597 |
| IOP | 14.40(1.85) | 13.73(3.80) | 0.725 | 13.90(3.15) | 13.98(3.21) | 0.569 |
| Ocular axis | 23.94(0.80) | 23.87(1.48) | 0.839 | 23.91(1.05) | 23.91(1.30) | 0.163 |
| Vessel density | ||||||
| Peripapillary | ||||||
| Whole | 17.25(1.70) | 16.78(2.76) | 0.45 | 16.53(2.16) | 16.90(2.13) | 0.977 |
| Inner ring | 17.59(2.55) | 16.96(3.21) | 0.12 | 18.07(2.68) | 16.87(2.47) | 0.031 |
| Temporal | 17.50(3.20) | 16.38(3.69) | 0.198 | 18.05(4.05) | 16.50(3.08) | 0.281 |
| Superior | 18.75(1.25) | 17.85(3.19) | 0.039 | 18.78(1.24) | 17.80(3.05) | 0.004 |
| Nasal | 16.65(4.00) | 16.80(4.59) | 0.307 | 17.13(3.20) | 15.75(4.63) | 0.093 |
| Inferior | 17.90(2.05) | 17.70(2.80) | 0.187 | 18.35(1.89) | 17.05(2.73) | 0.082 |
| Outer ring | 17.78(2.69) | 17.26(3.33) | 0.775 | 16.80(3.14) | 17.78(2.44) | 0.701 |
| Temporal | 18.65(2.70) | 17.58(2.48) | 0.377 | 18.63(3.13) | 17.50(2.45) | 0.549 |
| Superior | 18.35(2.35) | 18.00(2.83) | 0.16 | 18.13(2.84) | 18.55(2.63) | 0.235 |
| Nasal | 15.73(3.63) | 16.35(4.36) | 0.921 | 15.55(3.70) | 16.30(4.23) | 0.615 |
| Inferior | 18.45(3.05) | 18.43(2.74) | 0.807 | 18.50(3.08) | 18.35(2.63) | 0.817 |
| Macula | ||||||
| Whole | 12.60(4.34) | 13.43(5.10) | 0.364 | 13.55(5.05) | 12.80(5.43) | 0.942 |
| Inner ring | 12.37(4.20) | 13.94(5.52) | 0.173 | 13.31(3.95) | 13.23(6.32) | 0.922 |
| Temporal | 12.70(6.45) | 12.70(6.83) | 0.489 | 13.40(6.31) | 11.80(6.43) | 0.751 |
| Superior | 12.60(3.45) | 13.08(5.10) | 0.322 | 12.88(4.35) | 12.85(6.50) | 0.991 |
| Nasal | 12.33(6.71) | 15.18(7.29) | 0.13 | 12.60(5.30) | 12.50(9.18) | 0.655 |
| Inferior | 11.96(3.48) | 13.30(4.96) | 0.285 | 12.95(4.15) | 13.15(5.65) | 0.462 |
| Outer ring | 13.88(4.21) | 14.88(4.60) | 0.375 | 14.79(4.71) | 13.93(4.78) | 0.826 |
| Temporal | 12.55(4.90) | 12.70(6.95) | 0.792 | 13.05(5.00) | 12.30(6.76) | 0.887 |
| Superior | 13.65(4.85) | 14.90(4.30) | 0.468 | 14.95(4.86) | 14.75(4.16) | 0.864 |
| Nasal | 16.00(2.68) | 17.78(4.39) | 0.281 | 16.55(2.80) | 16.35(5.35) | 0.902 |
| Inferior | 13.56(2.72) | 14.05(3.97) | 0.633 | 14.15(5.30) | 14.10(5.80) | 0.433 |
| Perfusion density | ||||||
| Peripapillary | ||||||
| Whole | 0.430(0.045) | 0.425(0.079) | 0.565 | 0.420(0.062) | 0.430(0.061) | 0.910 |
| Inner ring | 0.453(0.084) | 0.448(0.084) | 0.24 | 0.476(0.082) | 0.439(0.055) | 0.046 |
| Temporal | 0.418(0.088) | 0.394(0.091) | 0.25 | 0.428(0.096) | 0.392(0.087) | 0.418 |
| Superior | 0.482(0.051) | 0.473(0.092) | 0.114 | 0.501(0.054) | 0.471(0.074) | 0.011 |
| Nasal | 0.455(0.093) | 0.455(0.134) | 0.401 | 0.467(0.080) | 0.444(0.147) | 0.311 |
| Inferior | 0.494(0.054) | 0.476(0.078) | 0.317 | 0.497(0.045) | 0.448(0.081) | 0.061 |
| Outer ring | 0.439(0.073) | 0.431(0.098) | 0.912 | 0.413(0.080) | 0.437(0.071) | 0.509 |
| Temporal | 0.453(0.077) | 0.426(0.069) | 0.389 | 0.453(0.081) | 0.427(0.069) | 0.764 |
| Superior | 0.468(0.046) | 0.467(0.088) | 0.443 | 0.462(0.067) | 0.474(0.081) | 0.196 |
| Nasal | 0.405(0.103) | 0.416(0.129) | 0.834 | 0.408(0.113) | 0.415(0.122) | 0.668 |
| Inferior | 0.463(0.070) | 0.471(0.077) | 0.67 | 0.463(0.077) | 0.465(0.071) | 0.673 |
| Macula | ||||||
| Whole | 0.298(0.116) | 0.319(0.135) | 0.265 | 0.327(0.129) | 0.312(0.137) | 0.638 |
| Inner ring | 0.279(0.107) | 0.323(0.147) | 0.145 | 0.304(0.102) | 0.305(0.156) | 0.882 |
| Temporal | 0.275(0.098) | 0.288(0.125) | 0.69 | 0.312(0.158) | 0.278(0.165) | 0.611 |
| Superior | 0.296(0.086) | 0.319(0.125) | 0.333 | 0.305(0.103) | 0.295(0.168) | 1 |
| Nasal | 0.284(0.155) | 0.357(0.181) | 0.089 | 0.291(0.114) | 0.283(0.228) | 0.683 |
| Inferior | 0.276(0.084) | 0.314(0.121) | 0.213 | 0.297(0.086) | 0.300(0.138) | 0.427 |
| Outer ring | 0.331(0.108) | 0.367(0.127) | 0.264 | 0.364(0.123) | 0.333(0.127) | 0.590 |
| Temporal | 0.303(0.129) | 0.305(0.192) | 0.717 | 0.315(0.139) | 0.296(0.186) | 0.970 |
| Superior | 0.320(0.112) | 0.374(0.117) | 0.297 | 0.376(0.123) | 0.368(0.117) | 0.641 |
| Nasal | 0.383(0.073) | 0.425(0.151) | 0.246 | 0.392(0.082) | 0.382(0.156) | 0.928 |
| Inferior | 0.326(0.073) | 0.342(0.106) | 0.566 | 0.346(0.138) | 0.335(0.149) | 0.591 |
| FAZ area (mm2) | 0.223(0.078) | 0.230(0.084) | 0.756 | 0.225(0.080) | 0.215(0.135) | 0.490 |
| FAZ perimeter(mm) | 1.95(0.35) | 1.98(0.38) | 0.771 | 2.00(0.28) | 1.96(0.56) | 0.628 |
| FAZ circularity | 0.697(0.027) | 0.703(0.048) | 0.582 | 0.700(0.020) | 0.710(0.078) | 0.102 |
BMI: Body Mass Index; MoCA: Montreal Cognitive Assessment; IOP: intra-ocular pressure; FAZ: Foveal Avascular Zone