Table 8. Association of carotid wall volume (mm3) with NO2 within co-pollutant exposure tertiles.
|
Overall
N = 6223 |
Low O
3
14.2–22.9 ppb N = 1941 |
Mid O
3
23.0–26.3 ppb N = 2296 |
High O
3
26.3–39.1 ppb N = 1986 |
|||||
|
Effect
(95% CI) |
p- |
Effect
(95% CI) |
p- |
Effect
(95% CI) |
p- |
Effect
(95% CI) |
p- | |
| Model 1 | -10.1 (-14.3,-5.95) | <.0001 | 0.44 (-5.33,6.21) | 0.8821 | -4.72 (-13.4,3.95) | 0.2857 | -27.5 (-35.1,-20.0) | <.0001 |
| Model 2 | -11.2 (-15.0,-7.32) | <.0001 | 6.95 (-1.29,15.18) | 0.0981 | -6.57 (-14.5,1.38) | 0.1054 | -27.7 (-34.6,-20.8) | <.0001 |
| Model 3 | -11.0 (-14.9,-7.10) | <.0001 | 7.06 (-1.19,15.31) | 0.0935 | -5.80 (-13.7,2.13) | 0.1514 | -28.0 (-34.9,-21.0) | <.0001 |
| Model 4 | -11.8 (-16.2,-7.31) | <.0001 | 7.65 (-1.49,16.78) | 0.1008 | -7.79 (-16.2,0.65) | 0.0706 | -31.8 (-39.6,-23.9) | <.0001 |
|
Low PM
2.5
(1.78–5.64 μg/m 3 ) N = 1903 |
Mid PM
2.5
5.65–8.18 μg/m 3 N = 1898 |
High PM
2.5
8.18–11.2 μg/m 3 N = 2422 |
||||||
|
Effect
(95% CI) |
p- |
Effect
(95% CI) |
p- |
Effect
(95% CI) |
p- | |||
| Model 1 | -10.1 (-14.3,-5.95) | <.0001 | -5.36 (-14.4,3.68) | 0.2450 | -13.5 (-23.3,-3.61) | 0.0074 | -14.8 (-22.3,-7.29) | 0.0001 |
| Model 2 | -11.2 (-15.0,-7.32) | <.0001 | -7.41 (-15.8,0.96) | 0.0828 | -11.1 (-20.7,-1.61) | 0.0219 | -15.4 (-22.3,-8.59) | <.0001 |
| Model 3 | -11.0 (-14.9,-7.10) | <.0001 | -7.68 (-16.1,0.77) | 0.0749 | -11.1 (-20.6,-1.46) | 0.0239 | -14.7 (-21.6,-7.73) | <.0001 |
| Model 4 | -11.8 (-16.2,-7.31) | <.0001 | -8.00 (-18.0,2.01) | 0.1173 | -11.8 (-22.2,-1.26) | 0.0281 | -15.3 (-22.5,-8.18) | <.0001 |
Presented data are adjusted CWV estimates (95% CI) per 5 ppb increase for NO2 from a linear mixed model with centre modelled as a random intercept. Model 1, unadjusted. Model 2, adjusted for age, (sex), and ethnicity. Model 3 further adjusted for the INTERHEART risk score, education and workplace location. Primary model 4 further adjusted for walkability categories, material factor score and social factor score.