Figure 2.

Dose Titration of AZD3965 for [¹⁸F]FPA PET/CT Cardiac Imaging. (a) Increasing concentrations of AZD3965 (0, 0.05, 0.5, 5 mg/kg) were co-injected with 9.25–11.1 MBq (250–300 μCi) of [¹⁸F]FPA. The mice were imaged for 60 min by PET/CT starting at 60 min p.i. (n = 4). Hearts are indicated by white arrows. Time activity curves for (b) hearts, (c) livers, (d) brains, and (e) kidneys taken from image-based quantitation of sixty-minute dynamic PET acquisitions (12 × 5 min frames) starting at 20- and 60-min p.i. are shown. Kinetic differences between animals co-injected with AZD3965 or vehicle (DMSO) are illustrated (mean ± S.E.M.; n = 9–11; *p < 0.05, two-way ANOVA, Šídák post hoc).