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[Preprint]. 2024 Oct 14:rs.3.rs-4921634. [Version 1] doi: 10.21203/rs.3.rs-4921634/v1

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Chemotherapy induced surviving tumor cells share common phenotypes and pathways for survival. (A) UMAP of all conditions for PC3 cells. (B) Comparison of DEGs between MDA-MB-231 large-D10 and PC3 large-D10 cells. Between cisplatin and docetaxel treatments, MDA-MB-231 and PC3 share 309 upregulated genes compared to their respective controls. (B) Genecode annotations for 309 shared genes. (D-E) LFC of shared 309 genes for PC3 vs MDA-MB-231 for docetaxel and cisplatin treatments, respectively. (F) CHEA3 transcription factor enrichment of the shared 309 genes between MDA-MB-231 and PC3 cells. (G) Hallmark enrichment analysis of 309 shared genes. (H) Single cell Hallmark gene set enrichment analysis for all PC3 cells.