Table 3:

Multivariate analysis using cox-proportional hazard model to analyze impact of demographic and clinical parameters on progression-free survival according to generation of EGFR TKI received

Variable	1st /2nd Gen, HR	1st /2nd Gen, 95% CI	3rd Gen, HR	3rd Gen, 95% CI
Sex	Reference	0.068 to 1.553	Reference	1.147 to 5.513
Female	0.3762		2.515
Male
Ethnicity	Reference	0.840 to 7.863	Reference	0.566 to 2.998
Asian/Pacific Islander	2.462		1.315
Other
Smoking Status	Reference	2.467 to 118.1	Reference	0.435 to 2.173
Never smoker	15.12		1.006
Ever smoker
Tumor Histology	Reference	0.248 to 22.64	Reference	0.875 to 15.90
Adenocarcinoma	2.752		4.271
Other
Brain Mets	Reference	2.082 to 18.00	Reference	0.652 to 2.789
No	5.940		1.379
Yes
BMI	0.896	0.796 to 1.00	0.969	0.895 to 1.039
Age at Treatment Initiation	0.981	0.943 to 1.019	1.024	0.996 to 1.055
Albumin	Reference	0.115 to 2.938	Reference	0.139 to 4.093
≥ 3.2	0.673		0.971
< 3.2
NLR	Reference	0.198 to 2.021	Reference	0.309 to 1.255
< 5	0.653		0.631
≥ 5
PLR	Reference	0.521 to 6.010	Reference	0.634 to 3.981
< 180	1.789		1.598
≥ 180