Figure 6. Importin α regulates mitotic spindle orientation through mediating NuMA localization to the metaphase cortex and maintenance at the cell cortex through anaphase in a palmitoylation dependent manner.

Proposed model of palmitoylated importin α’s role in astral microtubule anchoring as a transporter of NuMA and a scaffold at the cell cortex for astral microtubule anchoring proteins to maintain cortical localization throughout metaphase and anaphase.