Table 1.

Characteristics of reported patients with granulomatous colitis associated to HPS

Ref.	Yr	Country	n	Age in yr	Sex	GI symptoms	Endoscopy findings	HPS	Treatment	Outcome
Alexis et al	2006	United States	4	28	F	Intermittent diarrhea and rectal pain, rectal pain and occasional blood, lower GI bleeding	Colitis with mucopurulent exudate; proctitis	UKN	Infliximab and azathioprine	Improvement
				47	F	Pain and occasional GI bleeding	Proctitis	UKN	Infliximab, 6-MP	Improvement
				33	M	Lower GI bleeding	Moderate rectitis	UKN	Infliximab, 6-MP	Colectomy
				53	M	GI bleeding	Segmental colitis with ulcerations	UKN	Mesalazine, 6-MP, infliximab	Small bowel resection
Felipez et al	2009	United States	1	17	M	Bloody diarrhea	Melanosis, deep colorectal ulcerations	Type 1	6-MP, infliximab	Improvement
Hazzan et al	2006	United States	6	32	F	Chronic diarrhea, lower GI bleeding	UKN	Type 1	UKN	Subtotal colectomy; completion proctectomy + end ileostomy; small bowel resection
				52	M	Lower GI bleeding	UKN	UKN	UKN	Subtotal colectomy + end ileostomy
				30	M	Diarrhea, lower GI bleeding, perianal abscesses	UKN	Type 1	UKN	Subtotal colectomy + ileorectal anastomosis
				4	M	Chronic diarrhea and perianal abscess	UKN	Type 1	UKN	UKN
				29	M	Severe diarrhea	UKN	Type 1	UKN	UKN
				11	M	Chronic diarrhea	UKN	Type 1	UKN	UKN
Kouklakis et al	2007	Greece	1	42	F	Abdominal pain and bloody diarrhea	Segmental colitis with multiple ulcers, deep ileal ulcers	UKN	Azathioprine, infliximab	Improvement
Yoshiyama et al	2009	Japan	1	28	M	UKN	Proctitis	Type 6	Mesalazine, azathioprine, infliximab	Improvement
Mora et al	2011	United States	1	53	M	GI bleeding	UKN	UKN	Mesalazine, 6-MP, infliximab	Improvement

6-MP, 6-Mercaptopurine; F, female; GI, gastrointestinal; M, male; UKN, unknown.