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. 2024 Nov 1;134(21):e178949. doi: 10.1172/JCI178949

Figure 4. Vitamin D tolerization does not reverse MS DCs’ inflammatory fingerprint.

Figure 4

(A) DNA methylation heatmap of 6 versus 8 samples of HD and MS tolDCs. The heatmap includes all CpG-containing probes displaying DMPs (FDR < 0.05, β > 0.05) in the HD tolDCs–MS tolDCs contrast. (B) Violin plots showing the general distribution of DNA methylation across hyper- or hypomethylated clusters in HD tolDCs and MS tolDCs. (C) Volcano plots of gene expression showing HD–MS tolDCs contrast, with binary logarithm of fold change on the x axis and negative decimal logarithm of FDR on the y axis. Differential expression of genes was calculated as described earlier. (D) Bar plot depicting the TF activity predicted from mRNA expression of target genes with DoRothEA v2.0 in the HD–MS tolDCs contrast in terms of NES. Enriched regulons were identified as described earlier.