Skip to main content
. 2024 Sep 12;134(21):e180157. doi: 10.1172/JCI180157

Figure 6. Serotonin induces hypoglycemia during meal tolerance test; hypoglycemia is blocked by cyprophetadine and more specifically by ketanserin.

Figure 6

Reductions in glucose are blocked by the serotonin antagonist cyproheptadine and the specific serotonin receptor 2 antagonist ketanserin. (A) Scheme showing administration of cyproheptadine (50 mg/kg) or saline and, after 30 minutes, oral gavage with 200 μL of Ensure, insulin injection (2 U/kg), and administration of serotonin (20 mg/kg) or saline in C57BL/6J mice. MMTT, mixed meal tolerance test. (B) Glucose levels during experiment. (C) Scheme showing administration of ketanserin (5 mg/kg) and exogenous administration of serotonin (20 mg/kg) or saline in C57BL/6J mice. (D) Glucose levels after serotonin or saline injection. (E and F) Insulin levels (E) and GLP-1 levels (F) after serotonin or saline injection. In all panels, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by 2-way ANOVA with Tukey’s multiple-comparison test.